On stardate 47391.2, Lt. Worf visited a number of alternate realities after passing through a quantum fissure in the space-time continuum while traveling on a shuttle. In the last reality he visited, the bridge of the Enterprise-D featured a radically different layout than in the prime reality. While the structure itself was unchanged, the captain’s chair sat alone on a raised platform which extended forward between the operations and flight control stations; the circuitry access panels at the sides of the bridge featured a different design and were colored red; and a large glass master systems display sat between the tactical arch and the aft consoles; among other smaller changes.
(You can read up on the research done onto the changes to the set during the 7 seasons of TNG and ‘Generations’ here: http://www.ex-astris-scientia.org/inconsistencies/enterprise-d-bridge.htm)